Personal tools

Haematology-Oncology

Congenital and acquired disorders of haematopoiesis are usually acute life-threatening diseases whose diagnosis and treatment require interdisciplinary cooperation between specialised laboratories and outpatient or inpatient therapy units. In addition to congenital syndromal diseases in which bone marrow insufficiency occurs early after birth, some haematopoietic defects may manifest themselves later in childhood or even in adulthood. In some genetic alterations, combined disorders of the immune system and haematopoiesis typically occur.

Acquired haematopoietic disorders such as severe aplastic anaemia and myelodysplastic syndromes can only be distinguished by comprehensive morphological and molecular or cytogenetic investigations. In most cases in childhood and in some cases in adult patients, the only treatment option is allogeneic hematopoietic stem cell transplantation, a highly specialised form of treatment that can only be performed at experienced centres. Acute leukaemias in children and adults have recently been subdivided into many subgroups thanks to the intensification of molecular diagnostics. The rapid gain in knowledge in the field of molecular pathomechanisms has now led to causal therapy options for some malignant haematological diseases. In some cases, cure rates of > 80% can be achieved in this way.

The diagnosis and therapy of rare blood coagulation diseases require competent diagnostics, family counselling and interdisciplinary cooperation between paediatrics and adult medicine.

Bleeding, but also thrombosis and tumour-like changes can be caused by congenital vascular diseases. In addition to the frequently occurring infantile haemangiomas in newborns and infants, there are also other much less frequently occurring benign, locally aggressive or even malignant vascular tumours. In addition, congenital malformations of the lymphatic and blood vessels are important. These occur as simple malformations (lymphatic, venous, capillary, arterio-venous malformations), in the combination of several types of vessels or also in connection with other tissue malformations (above all bone, fat, musculature, CNS, heart, internal organs) in the context of large or also small growth syndromes. The necessary diagnostics and the decision on the use of therapeutic measures require a lot of experience and often also interdisciplinary coordination.

If there is an accumulation of tumour diseases in the family or even in a patient and if tumours occur at a younger age, competent genetic and interdisciplinary counselling should be carried out. Thanks to novel DNA sequencing methods, these familial diseases can be classified more quickly and accurately, with considerable consequences for the patients and their relatives, and appropriate diagnostic or early detection programmes can be initiated.

The Clinic and Polyclinic for Paediatrics and Adolescent Medicine, Clinic and Polyclinic for Gynaecology and Obstetrics, Medical Clinic and Polyclinic I  as well as the Institute for Clinical Geneticsare involved in the cluster.

Clinic and Polyclinic for Paediatrics and Adolescent Medicine, Medical Clinic and Polyclinic I, Institute for Clinical Genetics

Diseases

Congenital haematopoietic disorders:

Fanconi anaemia
Diamond-Blackfan anaemia
Shwachman-Diamond syndrome
Dykeratosis congenita
Chronic neutropenia


Acquired haematopoietic disorders:

Severe aplastic anaemia (SAA)
Paroxysmal nocturnal haemoglobinuria (PNH)
Myelodysplastic syndromes (MDS)
Myeloproliferative disorders (MPN)


Congenital and acquired haemorrhagic diatheses:

Haemophilia (haemophilia A and B)
Inhibited haemophilia
Von Willebrand-Jürgens syndrome
Deficiency of coagulation factors
Diseases of the blood platelets (thrombocytes)


Diseases of blood and lymph vessels:

Benign vascular tumours (infantile and congenital haemangioma, granuloma pyogenicum etc.)
Locally aggressive vascular tumours (caposiform haemangioendothelioma, etc.)
Malignant vascular tumours
Lymphatic, venous, capillary, arterio-venous malformation
Vascular malformations associated with other anomalies (Klippel-Trénaunay syndrome, etc.)
Primary lymphoedema
Osler's disease


Rare forms of leukaemia:

Acute promyelocytic leukaemia
Ph+ Chronic myeloid leukaemia in childhood and adolescence
Acute myeloid leukaemia with recurrent cytogenetic changes
CEBPA biallelic mutant acute myeloid leukaemia
NPM1- Acute myeloid leukaemia
FLT3-ITD acute myeloid leukaemia
RUNX1-mutated acute myeloid leukaemia
Acute myeloid leukaemia with MDS-associated changes
Therapy-related MDS or acute myeloid leukaemia
Acute lymphoblastic leukaemia of the adult


Familial cancers:

Familial breast and ovarian cancer
Familial colorectal cancer syndromes
Von Hippel-Lindau syndrome
Multiple endocrine neoplasia syndrome (MEN)
Retinoblastoma
Neurofibromatosis
Li Fraumeni syndrome
Familial tumours of various organ systems

Special consultation hours

Integration into existing research networks

Clinic and Polyclinic for Gynaecology and Obstetrics

In gynaecology, we also treat rare tumour diseases, among others, which can limit patients to a not inconsiderable extent.

We also care for patients with congenital malformations of the external and internal genitals in girls and young women. Chromosomal disorders or congenital receptor defects often represent a considerable interference in the lives of the patients when they are diagnosed. Often, the diagnoses mentioned are not made until the onset of puberty and thus possibly also mean a disturbance of gender identity or an intervention in family planning.

Diseases 

  • Mayer-Rokitanski-Küster-Hauser syndrome
  • Complete or partial androgen resistance
  • Turner syndrome


Malignant diseases:

  • Vulvar carcinoma
  • Vaginal carcinoma
  • Uterine sarcomas

Special consultation hours

  • Consultation hour for Familial Tumour Risk (GYN)

Further Information >> 

Integration into existing research consortia

  • German Consortium for Familial Breast and Ovarian Cancer
    (GC-HBOC , German Consortium of Hereditary Breast and Ovarian Cancer)

  • CIMBA - Consortium of Investigators of Modifiers of BRCA1/2
     Further Information >>