Meeting of the Working Group on Olfaction and Gustation of the German ENT society 2015

Invitation

Dear colleagues:

We would like to invite you to the meeting of the Working Group on Olfaction and Gustation of the German ENT society in Erlangen. For the 3rd time, the meeting will be international; thus, the primary congress language will be English. Of course, talks may still be delivered in German, but we kindly request slides to be written in English. If possible, discussions should be held in English, too.

Just «as usual» we will have a special event on Friday evening and will go to the Congress Dinner in Nürnberg.

We are looking forward to welcome you in Erlangen soon!

Prof. Dr. med. Dr. h.c. H. Iro, Head of Department
Dr. med. T. Meusel,
Department of Otorhinolaryngology, FAU Erlangen
Waldstraße1, 91054 Erlangen

Prof. Dr. med. A. Ludwig, Head of Institute
PD Dr. med. B. Renner
Institute of Pharmacology, FAU Erlangen
Krankenhausstr. 9, 91054 Erlangen

Prof. Dr. med. univ. W. Neuhuber, Head of Department I
Institute of Anatomy, FAU Erlangen
Krankenhausstr. 9, 91054 Erlangen

Prof. Dr. med. Dr. h.c. K.-B. Hüttenbrink, Head of Department
Department of Otorhinolaryngology, University Köln
Kerpener Str. 62, 50937 Köln

Organisation:       Dr. med. T. Meusel, PD Dr. med. B. Renner, Prof. Dr. med. T. Hummel

Congress venue

Institute of Anatomy, Department I
Friedrich-Alexander University of Erlangen-Nürnberg
Krankenhausstraße 9, D-91054 Erlangen, Germany

How to get there

Arrival by car:

At the Institute of Anatomy, there is no public parking. Paid parking is available e.g. in the parking garage of University hospitals (see plan, access Palmsanlage). The walk from the parking garage to the Institute takes about ten minutes.

Arrival by train:

From the station, the Institute can be reached on foot in about eight minutes. Erlangen is a stop for ICE (Intercity Express), IC (Intercity), RE (Regional Express) und RB (Regional Train).

Arrival by plane:

The nearest domestic airport is located north of Nürnberg, the nearest international airports are located in München and Frankfurt. Frankfurt and München are well connected with Nürnberg by train and plane. The distance from the airport of Nürnberg to the city center of Erlangen is about 15 km.

(http://www.anatomie1.med.uni-erlangen.de/)

Abstract deadline for posters / talks:

20. November 2015

(to be submitted to Prof. Dr. Thomas Hummel, email: thummel(at)mail.zih.tu-dresden.de)

Congress fee (including evening programm + Congress Dinner): 50 €

for students (please provide legitimation): 20 €

Pre-Registration (for administrative purposes):

On-site office:

Angela Meindl
Institute of Pharmacology and Toxicology,
FAU Erlangen-Nürnberg,
Krankenhausstr. 9, D-91054 Erlangen

Tel.: +49 (0)9131/85-22771

Fax: +49 (0)9131/85-26898

E-Mail:       angela.meindl(at)fau.de

or               bertold.renner(at)fau.de

„Aussteller“ / „Sponsors“

• MEDA Pharma GmbH  Co. KG, Bad Homburg
• Karl Storz Endoskope, Tuttlingen
• Hennig Arzneimittel, Flörsheim am Main

Hotel Reservation:

For special rates, please visit (before 02.11.15):

http://www.erlangenmarketing.de/olf/

or feel free to contact

Katja Rüth
Erlanger Tourismus und Marketing Verein e.V.
Rathausplatz 3
91052 Erlangen

Tel: +49 (0) 9131 8951-11
Fax: +49 (0) 9131 8951-51
katja.rueth@etm-er.de

For German MDs and continuing medical education (CME): Fortbildungspunkte der BLÄK werden beantragt.

Scientific program

Detail

Download program and abstracts

Abstracts

Olfactory testing in PD diagnosis - European and German recommendations.
Antje Hähner, Dresden: Antje.Haehner

Administration of the "Sniffin' Sticks": Methodological Concerns
Thomas Hummel and Shangwa Lee, Dresden: thummel@mail.zih.tu-dresden.de

Phantosmia: Diagnostic and therapeutical considerations
Landis Basile Nicolas, Geneva: Basile.Landis@hcuge.ch

A self-administered test of taste function using “taste-strips”
¹Mueller CA,^{1, 2}Wolf A,¹Varga L, ¹Wittibschlager L, ³Renner B
¹Department of Otorhinolaryngology, Medical University of Vienna; ²Department of Otorhinolaryngology, Medical University Graz; ³Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuernberg. christian.a.mueller@meduniwien.ac.at

Background: Assessment of gustatory function with impregnated taste strips is an established and validated method. In clinical routine, application of the tests is often limited due to lack of time or costs associated with administering the test. Objective: The aim of the study was to develop a procedure suitable for self-administration of the ‘Taste Strips’ test. Methods: The investigated participants (n=65, 22 males and 43 females, mean age 36.7±19.2 years, range 20 to 83 years) were tested twice in a randomized cross-over procedure. On one occasion, an examiner administered the established and validated ‘taste strips’ test. On another occasion, test subjects administered the taste strips themselves. Results of both test-methods were compared. Results: The mean score (±SD) of the assisted taste test (11.6±2.6) was significantly lower compared to the mean self-administered taste test that yielded 12.3±2.6 points (Wilcoxon-Test: z=2.836, p<0.01). Comparison of mean values showed minimal difference of the tested procedures of 0.7±1.9 points with a significant positive correlation of test results (r₆₅=0.734, p<0.01). Conclusion: Although a small difference between test results was observed, the new test procedure seems to be an adequate screening tool for assessment of taste function with less personnel effort leading to improved management of patients with chemosensory disorders.

Olfactory function in patients with hyposmia compared to healthy subjects - An fMRI study.
Pellegrino R, Hähner A, Bojanowski V, Hummel C¹, Gerber J, Hummel T; Dresden: pellegrino.robert@gmail.com

The aim of this fMRI-study was to investigate the central processing of odors in patients with hyposmia compared to healthy controls. Eleven hyposmic and 12 healthy, normosmic subjects participated in the study.  Olfactory functionality was assessed using a standardised psychpysical test including odor threshold, odor discrimination and odor identification.  During fMRI sessions subjects were exposed to two different food-related odors (coffee and peach); The activations of the normosmic group were localized in typical olfactory areas (insula, OFC, limbic lobe and amygdala). The hyposmic group showed similar regions of activation (insula, OFC, limbic system), however, less activation was found in the amygdala, but higher activation were shown in the right parahippocampal and both the left and right posterior cingulate gyrus which is assumed to play an important role in the processing and remembrance of memories.  These results indicate similar central olfactory processing among groups, yet subjects with partial loss seem to attempt to compensate smell impairment with odor memory or higher motivation to smell.

A case of olfactory meningeoma
Florian Uecker, Berlin: Fc.Uecker@charite.de

Riechvermögen von Patienten mit und ohne „aspirin exacerbated respiratory disease“ (AERD) - eine longitudinale Studie
V. Gudziol, C. Sonnefeld, D.  Koschel, T. Hummel; Dresden; volker.gudziol

Ziel und Methodik: Das Riechvermögen ausgedrückt als SDI-Wert sollte bei Patienten mit chronisch polypöser Rhinosinusitis (CRS) mit und ohne Analgetikaintoleranz vor und 6 Monate nach Aspirin (ASS)-Intoleranz Testung bzw.  Desaktivierung mithilfe der Sniffin’ Sticks Testung bestimmt werden. Ergebnisse: Bei 15 Patienten wurden ein AERD diagnostiziert und bei 15 Patienten ein AERD ausgeschlossen. In der Eingangsuntersuchung zeigten die Patienten mit AERD ein signifikant (p=0,02 bzw. p=0,01) schlechteres Riechvermögen (SDI-Wert bzw. Identifikations-Wert: 18,1±8,9 bzw. 7,7±3,8) als die Patienten ohne AERD (SDI-Wert: 26,8±10,3 bzw. 11.7±4.5). In der Betrachtung der verwendeten Untertests fällt auf, dass im Identifikationstest der Unterschied zwischen den Patientengruppen signifikant war (p=0,03), jedoch nicht in den Test für Diskrimination und der Riechschwelle. 6 Monate nach ASS- Testung bzw. Desaktivierung konnte zwischen den Patientengruppen kein signifikanter Unterschied sowohl im SDI-Wert (p=0,14) als auch in den Untertests nachgewiesen werden. Schlussfolgerung: Der Identifikationstest ist am ehesten geeignet Unterschiede des Riechvermögens bei Patienten mit und ohne AERD zu diagnostizieren. Möglicherweise führte die Einnahme von ASS zu einem nicht signifikanten Anstieg des Riechvermögens in der AERD-Gruppe.

Hedonic hyperphagia: how smell and taste overrule intake control of palatable snack foods.
A. Hess ¹, T. Hoch ², S. Kress², S. Kreitz ¹, M. Pischetsrieder ^2
1 Department of Experimental and Clinical Pharmacology and Toxicology, Institute for Pharmacology and Toxicology, University of Erlangen-Nuremberg, Fahrstrasse 17, 91054 Erlangen, Germany; ² Department of Chemistry and Pharmacy, Food Chemistry, Emil Fischer Center, University of Erlangen-Nuremberg, Schuhstrasse 19, 91052 Erlangen, Germany
"Dr. Andreas Hess" andreas.hess@fau.de

Hedonic hyperphagia – eating for pleasure independent from hunger – is a well-known phenomenon. In a series of experiments rats were fed with either crushed potato chips (PC) or substitutes with different mixtures of fat and carbohydrates (FCH), which are the main ingredients of PC. We evaluated in these rats eating behavior in a two-choice preference test as well as mapped the whole brain activity by manganese enhanced MR. We were able to show, that compared to the standard food the snack food PC and to somewhat lesser extent FCH were able to 1.) significantly increase food seeking behavior and 2.) selectively modulate brain circuitry serving functions like reward and addiction, food intake, sleep and locomotion. Since the rats could only rely on olfactory and gustatory clues for differentiating between FC / FCH and standard food these basic sensory inputs are able to induce addiction like activity in the brain.

Increased H₂S-thresholds during exercises
Gudziol, H., Schneider, K., Seeber, H., Bitter, Th., Guntinas-Lichius, O.
Universitätsklinikum der Friedrich Schiller Universität, Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, Jena; hilmar.gudziol@med.uni-jena.de

The detection thresholds with 25 young healthy normosmics were evaluated at rest, during bicycle-ergometer strain and recreation with staircase method by flow-olfactometer. Computer-aided stimulation happened inhalation-synchronously at regular nasal breathing pattern with an ISI at least 60s. The duration of the stimuli was 2s. The concentration of H₂S varied from 0.001 to 0.0225ppm. The heart rate during the physical strain should be between 135 and 145 beats/min. In comparison to the rest condition the thresholds of detected H₂S concentrations during cycling increased to 42%, and compared to the recreation condition the volunteers under the ergometer-strain detected 61% higher H₂S concentrations. The reason of that smelling decrease is not well understood. May be cycling distracts from olfactory threshold examination.

Neural correlations of and interaction between homeostatic (thirst) and sensory-evoked emotions (olfactory disgust)
Hergen Friedrich, Lea Meier, Andreas Federspiel, Kay Jann, Yosuke Morishima, Roland Wiest, Werner Strik, Thomas Dierks, Basile Nicolas Landis; Bern, Geneva; hergen83@gmx.net

Introduction: A homeostatic imbalance is closely linked to the experience of emotions, for example disgust. Aim of the study was to give insight in the neural correlates of this emotional rivalry. Materials and Methods: A fMRI study was performed with twenty male subjects  that underwent olfactory stimulation in the state of water deprivation and satiation. Results: Hydration state specifically modulated the perception of the disgusting odor in subjective rating. Functional MRI data of  brain activity revealed a response to disgusting odor in following brain areas: insula bilaterally, right supramarginal gyrus and left frontal inferior operculum. Neuronal activity  was reduced in the left insular cortex during the experience of thirst. Discussion: Our results indicate a modulatory impact in the situation of emotional rivalry, because disgust experience was reduced both on subjective and neurobiological level.

Registration

Please let us know by email to Bertold Renner (bertold.renner(at)fau.de) whether you would like to participate or not:

I will participate at the meeting and will submit an abstract (untill Nov.20th): yes        no

I will participate without abstract submission:   yes       no

Title / Name:………………………………………………………….…………………………..…………………………………..

Affiliation:……………………………………………………………………………………………………………….………………………….

Student: yes:    no:

Download Flyer