Hematopoesis in health and disease
Dr. Tatyana Grinenko
Principal Investigator
Foto by Hagen Gebauer
Research focus
Hematopoietic stem cells (HSCs) give rise to all types of blood cells. Tight regulation of the rate of stem cell division and differentiation is important for the maintenance of the healthy blood and immune cell system during the life. Functional changes and accumulation of somatic mutations in hematopoietic stem cells and progenitor cells are a common cause for hematopoietic malignancies. Our group studies:
- Aging and possible mechanisms of HSC rejuvenation.
- Epigenetic regulation of HSC differentiation.
- Mechanisms of somatic mutation accumulation and HSCs malignant transformation.
- Bone marrow niche in health and malignant transformation.
Specific expertise
- Hematopoietic stem cells
- Inflammation stress models
- Stem cell fate decision and epigenetic
- Bone marrow niche
Funding
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Lab Members
Selected Publications
- Ramasz B, Krüger A, Reinhardt J, Sinha A, Gerlach M, Gerbaulet A, Reinhardt S, Dahl A, Chavakis T, Wielockx B, Grinenko T. Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases. Blood. 2019 Aug 21. doi: 10.1182/blood.2019000721.
- Grinenko T, Eugster A, Thielecke L, Ramasz B, Krüger A, Dietz S, Glauche I, Gerbaulet A, von Bonin M, Basak O, Clevers H, Chavakis T, Wielockx B. Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice. Nat Commun.,15;9(1):1898, 2018.
- Singh RP*, Grinenko T*, Ramasz B, Franke K, Lesche M, Dahl A, Gassmann M, Chavakis T, Henry I, Wielockx B. Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice. Stem Cell Reports. 10(6):1908-1919, 2018 (*equally contributed as first authors).
- Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C. Clonal expansion capacity defines two consecutive developmental stages of long-term hematopoietic stem cells. J Exp Med., 211 (2):209-15, 2014.