Inflammation and Myelopoiesis
Junior Prof. Dr. Lydia Kalafati
Jun. Prof Dr. Lydia Kalafati
Principal Investigator
![Platzhalter Bild Platzhalter Bild](https://www.uniklinikum-dresden.de/de/das-klinikum/kliniken-polikliniken-institute/klinische-chemie-und-laboratoriumsmedizin/images/dummybild_square.jpg)
Under Construction
Lab Members
Selected Publications
- Li X, Wang H, Yu X, Saha G, Kalafati L, Ioannidis C, Mitroulis I, Netea MG, Chavakis T, Hajishengallis G Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell. 2022 May 12;185(10):1709-1727.
- Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A, Ziogas A, Lesche M, Dahl A, Henry I, Subramanian P, Wielockx B, Murray P, Mirtschink P, Chung KJ, Schultze JL, Netea MG, Hajishengallis G, Verginis P, Mitroulis I, Chavakis T. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell. 2020 Oct 29;183(3):771-785.e12.
- Kalafati L, Hatzioannou A, Hajishengallis G, Chavakis T The role of neutrophils in trained immunity. Immunol Rev. 2023 Mar;314(1):142-157. Review.
- Alissafi T, Kalafati L, Lazari M, Filia A, Kloukina I, Manifava M, Lim JH, Alexaki VI, Ktistakis NT, Doskas T, Garinis GA, Chavakis T, Boumpas DT, Verginis P. Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity. Cell Metab. 2020 Oct 6;32(4):591-604.e7.
- Mitroulis I, Kalafati L, Bornhäuser M, Hajishengallis G, Chavakis T . Regulation of the Bone Marrow Niche by Inflammation. Front Immunol. 2020 Jul 21;11:1540. Review.
- Moorlag SJCFM, Rodriguez-Rosales YA, Gillard J, Fanucchi S, Theunissen K, Novakovic B, de Bont CM, Negishi Y, Fok ET, Kalafati L, Verginis P, Mourits VP, Koeken VACM, de Bree LCJ, Pruijn GJM, Fenwick C, van Crevel R, Joosten LAB, Joosten I, Koenen H, Mhlanga MM, Diavatopoulos DA, Chavakis T, Netea MG BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils. Cell Rep. 2020 Nov 17;33(7):108387..
- Jentho E, Ruiz-Moreno C, Novakovic B, Kourtzelis I, Megchelenbrink WL, Martins R, Chavakis T, Soares MP, Kalafati L, Guerra J, Roestel F, Bohm P, Godmann M, Grinenko T, Eugster A, Beretta M, Joosten LAB, Netea MG, Bauer M, Stunnenberg HG, Weis. Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme. S.Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2102698118
- Mitroulis I, Kalafati L, Hajishengallis G, Chavakis T . Myelopoiesis in the Context of Innate Immunity. J Innate Immun. 2018;10(5-6):365-372. Review.
- Kalafati L, Mitroulis I, Verginis P, Chavakis T, Kourtzelis I. Neutrophils as Orchestrators in Tumor Development and Metastasis Formation. Front Oncol. 2020 Dec 10;10:581457. Review