Hypoxia and Haematopoiesis
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Lab Members
Selected Publications
- Rauner, M, Murray, M, Thiele, S, Watts, D, Neumann, D, Gabet, Y, Hofbauer, L C, Wielockx, B. EPO/EPOR signaling in osteoprogenitor cells is essential for bone homeostasis and EPO-induced bone loss. Bone Res., in press (2021)
- Sormendi, S, Deygas, M, Sinha, A, Krüger, A, Kourtzelis, I, Le Lay, G, Bernard, M, Sáez, P. J, Gerlach, M, Franke, K, Meneses, A, Kräter, M, Palladini, A, Guck, J, Coskun, Ü, Chavakis, T, Vargas, P, Wielockx, B. HIF2α is a Direct Regulator of Neutrophil Motility. Blood, in press (2021)
- Watts, D, Stein, J, Meneses, A, Bechmann, N, Neuwirth, A, Kaden, D, Kruger, A, Sinha, A, Alexaki, V. I, Luis Gustavo, P.-R, Kircher, S, Martinez, A, Theodoropoulou, M, Eisenhofer, G, Peitzsch, M, El-Armouche, A, Chavakis, T, Wielockx, B, HIF1alpha is a direct regulator of steroidogenesis in the adrenal gland. Cell Mol Life Sci, 78: 3577-3590 (2021)
- Ramasz, B, Kruger, A, Reinhardt, J, Sinha, A, Gerlach, M, Gerbaulet, A, Reinhardt, S, Dahl, A, Chavakis, T, Wielockx, B* and Grinenko, T.* Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases. Blood 134: 1046-1058 (2019) (*equal contribution)
- Grinenko, T, Eugster, A, Thielecke, L, Ramasz, B, Kruger, A, Dietz, S, Glauche, I, Gerbaulet, A, von Bonin, M, Basak, O, Clevers, H, Chavakis, T and Wielockx, B. Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice. Nat Commun 9: 1898 (2018)
- Singh, R P*, Grinenko, T*, Ramasz, B, Franke, K, Lesche, M, Dahl, A, Gassmann, M, Chavakis, T, Henry, I and Wielockx, B. Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice. Stem Cell Reports 10: 1908-1919 (2018) (*equal contribution)
- Mitroulis, I, Chen, L S, Singh, R P, Kourtzelis, I, Economopoulou, M, Kajikawa, T, Troullinaki, M, Ziogas, A, Ruppova, K, Hosur, K, Maekawa, T, Wang, B, Subramanian, P, Tonn, T, Verginis, P, von Bonin, M, Wobus, M, Bornhauser, M, Grinenko, T, Di Scala, M, Hidalgo, A, Wielockx, B*, Hajishengallis, G* and Chavakis, T*. Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest 127: 3624-3639 (2017) (*equal contribution)
- Rauner, M, Franke, K, Murray, M, Singh, R P, Hiram-Bab, S, Platzbecker, U, Gassmann, M, Socolovsky, M, Neumann, D, Gabet, Y, Chavakis, T, Hofbauer, L C and Wielockx, B. Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells. J Bone Miner Res 31: 1877-1887 (2016)