Translational Oncology
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Lab Members
Selected Publications
- Elgendy, M, Ciro, M, Hosseini, A, Weiszmann, J, Mazzarella, L, Ferrari, E, Cazzoli, R, Curigliano, G, DeCensi, A, Bonanni, B, Budillon, A, Pelicci, P G, Janssens, V, Ogris, M, Baccarini, M, Lanfrancone, L, Weckwerth, W, Foiani, M and Minucci, S. Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3beta-MCL-1 Axis. Cancer Cell35: 798-815 e5 (2019)
- Elgendy, M, Fusco, J P, Segura, V, Lozano, M D, Minucci, S, Echeveste, J I, Gurpide, A, Andueza, M, Melero, I, Sanmamed, M F, Ruiz, M R, Calvo, A, Pascual, J I, Velis, J M, Minana, B, Valle, R D, Pio, R, Agorreta, J, Abengozar, M, Colecchia, M, Brich, S, Renne, S L, Guruceaga, E, Patino-Garcia, A and Perez-Gracia, J L. Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer. Int J Cancer145: 1991-2001 (2019)
- Abdel-Aziz, A K, Abdel-Naim, A B, Shouman, S, Minucci, S and Elgendy, M. From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib. Front Pharmacol8: 718 (2017)
- Elgendy, M, Abdel-Aziz, A K, Renne, S L, Bornaghi, V, Procopio, G, Colecchia, M, Kanesvaran, R, Toh, C K, Bossi, D, Pallavicini, I, Perez-Gracia, J L, Lozano, M D, Giandomenico, V, Mercurio, C, Lanfrancone, L, Fazio, N, Nole, F, Teh, B T, Renne, G and Minucci, S. Dual modulation of MCL-1 and mTOR determines the response to sunitinib. J Clin Invest127: 153-168 (2017)
- Ferrari, E, Bruhn, C, Peretti, M, Cassani, C, Carotenuto, W V, Elgendy, M, Shubassi, G, Lucca, C, Bermejo, R, Varasi, M, Minucci, S, Longhese, M P and Foiani, M. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Mol Cell67: 266-281 e4 (2017)
- Elgendy, M, Ciro, M, Abdel-Aziz, A K, Belmonte, G, Dal Zuffo, R, Mercurio, C, Miracco, C, Lanfrancone, L, Foiani, M and Minucci, S. Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner. Nat Commun5: 5637 (2014)
- Elgendy, M, Sheridan, C, Brumatti, G and Martin, S J. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell42: 23-35 (2011)
- Sheridan, C, Brumatti, G, Elgendy, M, Brunet, M and Martin, S J. An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs. Oncogene29: 6428-41 (2010)
- Logue, S E, Elgendy, M and Martin, S J. Expression, purification and use of recombinant annexin V for the detection of apoptotic cells. Nat Protoc4: 1383-95 (2009)