Forschung - Research
Driven by our mission as an academic GI center, we are dedicated to actively pursuing a deeper understanding of gastrointestinal disease causation, pathophysiology, and innovative treatment approaches.
Clinical Research
The GI unit is actively involved in pharmaceutical clinical trials on inflammatory bowel disease, primary sclerosing cholangitis, and primary biliary cirrhosis, investigating several new compounds. Additionally, the unit conducts research on liver diseases, including end-stage liver disease, TIPS, and ascites pumps. Clinical endoscopy research leverages AI and advanced tools to improve the diagnosis and treatment of gastrointestinal diseases, including the evaluation of new procedures and innovative devices. Clinical ultrasound research focuses on developing new imaging techniques and AI-driven analyses to enhance diagnostics and therapy
Research Groups
Research Group HampeLab
What happens inside our cells before a liver disease even becomes noticeable? And how can these early changes be used to develop better diagnostic and therapeutic approaches? The Hampe Group investigates these fundamental questions, with a particular focus on the metabolic dysfunction-associated steatotic liver disease and the hepatocellular carcinoma (HCC). Using cutting-edge technologies – from single-cell and spatial genomics to AI-driven analysis and biomarker research – we aim to gain a deeper understanding of disease mechanisms. Our goal is to develop innovative approaches for earlier detection and more targeted treatments.
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Dr. Juliane Heisig
Research Group SchneiderLab
Many human diseases arise from complex interactions between different organs and cellular systems. Traditional organ-centric models often fail to fully capture these dynamics. Our interdisciplinary and international team of researchers is committed to developing innovative therapies for gastrointestinal (GI) diseases by deciphering the molecular circuits involved in organ crosstalk. We focus on the gut-liver axis in liver diseases, including non-alcoholic fatty liver disease, acute liver failure, and cholestatic liver diseases. Additionally, we investigate how neuro-immune communication within the GI tract regulates complex processes such as inflammation and carcinogenesis. By leveraging state-of-the-art imaging and advanced multi-omics technologies, we aim to unravel the intricate interactions between cellular systems
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Anne-Kathrin Gerber
Research Group Clinical Studies Gastroenterology
The primary research focus of our group is Inflammatory Bowel Disease (IBD), which includes Crohn’s disease and ulcerative colitis. Despite recent advancements, achieving optimal treatment remains challenging, and clinical studies are essential to improving patient well-being in this multifactorial disease. Additionally, we conduct clinical studies on a broad spectrum of liver diseases. On the following pages, we present a selection of our clinical projects
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Research Group HybridEcho
Ultrasound technology plays a crucial role in modern medical diagnostics and therapy. Our interdisciplinary team of physicians, engineers, and computer scientists is advancing this field through innovative research. This includes technical developments such as advanced signal design, quantitative imaging techniques, and the integration of MEMS-based sensors, as well as multicentric clinical studies to validate these new technologies. Additionally, we are exploring AI-driven methods for data analysis and real-time decision support. Our work encompasses the development of novel ultrasound hardware, state-of-the-art software algorithms, and groundbreaking applications in non-invasive diagnostics and therapy
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Alexa Sieghardt
Research Group Next Generation Endoscopy
Endoscopy has revolutionized the diagnosis and treatment of gastrointestinal diseases. Our interdisciplinary team of physicians, engineers, and computer scientists is developing innovative technologies to further advance this field. These include advanced robotic tools with enhanced digital control, intelligent sedation methods, and AI-driven algorithms for improved diagnosis and therapy.Additionally, we are pioneering new simulator- and software-based training methods for endoscopists. Our research encompasses disease characterization, advanced treatment techniques, medical image recognition, and the development of novel technical procedures in endoscopy
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Catrein Stopp