Benutzerspezifische Werkzeuge

Publications

2021

  • Rodionov R.N., Peters F., Marschall U., L’Hoest H., Jarzebska N, Behrendt C.A. Initiation of SGLT2 Inhibitors and the Risk of Lower Extremity Minor and Major Amputation in Patients with Type 2 Diabetes and Peripheral Arterial Disease: A Health Claims Data Analysis, Accepted to Eur J Vasc Endovasc Surg.
  • Wang Y. and Angom R.S., Kulkarni T., Hoeppner L.H., Pal K., Wang E., Tam A.,  Valiunas R.A., Dutta S.K., Ji B., Jarzebska N., Chen Y., Rodionov R.N., Mukhopadhyay D, Dissecting VEGF-Induced Acute Versus Chronic Vascular Hyperpermeability: Essential Roles of Dimethylarginine Dimethylaminohydrolase-1. iScience 24, 103189, October 22, 2021
  • Steenblock C, Schwarz PEH, Ludwig B, Linkermann A, Zimmet P, Kulebyakin K, Tkachuk VA, Markov AG, Lehnert H, de Angelis MH, Rietzsch H, Rodionov RN, Khunti K, Hopkins D, Birkenfeld AL, Boehm B, Holt RIG, Skyler JS, DeVries JH, Renard E, Eckel RH, Alberti KGMM, Geloneze B, Chan JC, Mbanya JC, Onyegbutulem HC, Ramachandran A, Basit A, Hassanein M, Bewick G, Spinas GA, Beuschlein F, Landgraf R, Rubino F, Mingrone G, Bornstein SR. COVID-19 and metabolic disease: mechanisms and clinical management. Lancet Diabetes Endocrinol. 2021 Oct 4:S2213-8587(21)00244-8.
  • Kopaliani I., Jarzebska N., Brilloff S., Kolouschek A., Martens-Lobenhoffer J., Bornstein S.R., Bode-Böger S.M., Weiss N., Deussen A., Rodionov R.N., DDAH1 protects from angiotensin-II-induced myocardial and vascular remodeling. Am J Physiol Heart Circ Physiol. 2021 Nov 1;321(5):H825-H838.
  • Bornstein S.R., Voit-Bak K., Donate T., Rodionov R.N., Gainetdinov R, Tselmin S., Kanczkowski W., Achleitner M., Licinio J., Bauer M., Young A., Thuret S., Straube R., Wang Y, Bechmann N, Gregor Müller G. Chronic post Covid-19 syndrome and Chronic Fatigue Syndrome: Is there a role for neurotransmitters receptor antibodies and extracorporeal apheresis? Molecular Psychiatry, 2021 Jun 17:1-4Steenblock C., Richter S., Berger I., Barovic M., Schmid J., Schubert U., Jarzebska N., von Mässenhausen A., Linkermann A., Schürmann A., Pablik J., Dienemann T., Evert K., Rodionov R.N., Semenova N.Y., Zinserling V.A., Gainetdinov R.R., Baretton G., Lindemann D., Solimena M., Ludwig B., Bornstein S.R.. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun. 2021 Jun 10;12(1):3534.
  • Kozlova A.A.*, Ragavan V.N.*, Jarzebska N., Lukianova I.V., Bikmurzina A.E., Rubets E., Suzuki-Yamamoto T., Kimoto M., Mangoni A.A. Gainetdinov R.R., Weiss N., Bauer M, Markov A.G., Rodionov R.N.#, Bernhardt N.#, Divergent dimethylarginine dimethylaminohydrolase isoenzyme expression in the central nervous system. Cellular and Molecular Neurobiology, Cell Mol Neurobiol. 2021 May 20, * shared first authors. # shared senior authors.
  • Rodionov R.N., Beyer-Westendorf J., Bode-Böger S.M., Eggebrecht L., Konstantinides S., Martens-Lobenhoffer J., Nagler M., Prochaska J., Philipp Wild. Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism. Sci Rep. 2021 May 5;11(1):9569.
  • Rodionov R.N., Biener A., Spieth P., Achleitner M., Hölig K., Aringer M., Mingrone G., Corman V., Drosten C., Bornstein S.R., Tonn T., Kolditz M. Potential benefit of convalescent plasma transfusions in immunocompromised patients with COVID-19. Lancet Microbe. 2021 Apr;2(4):e138.
  • Maas R., Rodionov R.N., Phosphodiesterase-5 Inhibitors and Survival in Men With Coronary Artery Disease. J Am Coll Cardiol. 2021 Mar 30;77(12):1551-1553.
  • Bornstein S.R., Rubino F., Ludwig B., Rietzsch H., Schwarz P.E.H., Rodionov R.N., Khunti K., Hopkins D., Birkenfeld A.L., Boehm B., Amiel S., Holt R.I.G., Skyler J.S., DeVries J.H., Renard E., Eckel R.H., Zimmet P., Alberti K.G., Geloneze B., Chan J.C., Mbanya J.C., Onyegbutulem H.C., Ramachandran A., Basit A., Hassanein M., Spinas G.A., Beuschlein F., Mingrone G. Consequences of the COVID-19 pandemic for patients with metabolic diseases. Nat Metab. 2021 Mar;3(3):289-292
  • Jarzebska N., Karetnikova E.S., Markov A.G., Kasper M., Rodionov R.N., Spieth P.M. Scarred Lung. An Update on Radiation-Induced Pulmonary Fibrosis. Front Med (Lausanne). 2021 Jan 15;7:585756.

2020

  • Banjarnahor S., Rodionov R.N., König J., Maas R. Transport of L-Arginine Related Cardiovascular Risk Markers. J Clin Med. 2020 Dec 8;9(12):3975.
  • von Rhein C., Scholz T., Henss L., Kronstein-Wiedemann R., Schwarz T., Rodionov R.N., Corman V.M., Tonn T., Schnierle B.S. Comparison of potency assays to assess SARS-CoV-2 neutralizing antibody capacity in COVID-19 convalescent plasma. J Virol Methods. 2020 Dec 1;288:114031.
  • Rodionov R.N., Tselimin S., Rietzsch H, Julius U., Rechtzeitig starten. Lipoproteinapherese-Therapie. CardioVasc 2020; 20 (5): 23–24 (article in German)
  • Stautemas J., Jarzebska N., Shan Z.X., Blancquaert L., Everaert I., de Jager S., De Baere S., Hautekiet A., Volkaert A., Lefevere F.B.D., Martens-Lobenhoffer J., Bode-Böger S.M., Kim C.K., Leiper J., Weiss N., Croubels S., Rodionov R.N., Derave W. The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans. Eur J Appl Physiol. 2020 Sep 18. doi: 10.1007/s00421-020-04501-7. Online ahead of print.
  • Tonn T., Corman V.M., Johnsen M., Richter A., Rodionov R.N., Drosten C., Bornstein S.R. Stability and neutralising capacity of SARS-CoV-2-specific antibodies in convalescent plasma. Lancet Microbe. 2020 Jun;1(2):e63
  • Wali J.A., Koay Y.C., Chami J., Wood C., Corcilius L., Payne R.J., Rodionov R.N., Birkenfeld A.L., Samocha-Bonet D., Simpson S.J., O'Sullivan J.F. Nutritional and metabolic regulation of the metabolite Dimethylguanidino Valeric Acid - an early marker of cardiometabolic disease. Am J Physiol Endocrinol Metab. 2020 Sep 1;319(3):E509-E518.
  • Zinserling V.A., Semenova N.Y., Markov A.G., Rybalchenko O.V., Wang J., Rodionov R.N., Bornstein S.R. Inflammatory Cell Infiltration of Adrenals in COVID-19. Horm Metab Res. 2020 Sep;52(9):639-641.
  • Bornstein S.R., Voit-Bak K., Schmidt D., Morawietz H., Bornstein A.B., Balanzew W., Julius U., Rodionov R.N., Biener A.M., Wang J., Schulte K.M., Krebs P., Vollmer G., Straube R. Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19? Horm Metab Res. 2020 Jul;52(7):540-546.
  • Wali J.A., Jarzebska N., Raubenheimer D., Simpson S.J., Rodionov R.N., O'Sullivan J.F. Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms-A Narrative Review. Nutrients. 2020 May 21;12(5):1505.
  • Dalan R., Bornstein S.R., El-Armouche A., Rodionov R.N., Markov A., Wielockx B., Beuschlein F., Boehm B.O. The ACE-2 in COVID-19: Foe or Friend? Horm Metab Res. 2020 May;52(5):257-263.
  • Hulin J.A., Gubareva E.A., Jarzebska N.,  Rodionov R.N., Mangoni A.A., Tommasi S. Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) enzymes as an emerging therapeutic strategy to target angiogenesis and vasculogenic mimicry in cancer. Front Oncol. 2020 Jan 9;9:1455.

2019 and earlier

  • Jarzebska N., Georgi S., Jabs N., Brilloff S., Renke M., Rodionov R.N., Zietz C., Montresor S. Hohenstein B. Weiss N. Kidney and liver are the main organs of expression of a key metabolic enzyme alanine:glyoxylate aminotransferase 2 in humans. Atheroscler Suppl. 2019 Dec;40:106-112.
  • Rodionov R.N., Jarzebska N., Schneider A., Rexin A., Sradnick J., Brilloff S., Martens-Lobenhoffer J., Bode-Böger S.M., Todorov V, Hugo C., Weiss N., Hohenstein B. ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus. Atheroscler Suppl. 2019 Dec;40:100-105.
  • Jarzebska N., Mangoni A.A., Martens-Lobenhoffer J., Bode-Böger S.M., Rodionov R.N. The Second Life of Methylarginines as Cardiovascular Targets. Int J Mol Sci. 2019 Sep 17;20(18).
  • El-Agroudy N., Kurzbach A., Rodionov R.N., O’Sullivan J. Roden M., Birkenfeld A.L., Pesta D.H. Are lifestyle therapies effective for NAFLD treatment? Trends Endocrinol Metab. 2019 Oct;30(10):701-709.
  • Rodionov R.N., Begmatov H., Jarzebska N., Patel K., Mills M., Assaf M., Ghani Z., Khakshour D., Tamboli P., Patel M., Abdalla M., Martens-Lobenhoffer J., Bode-Böger S.M., Millan J.L., Weiss N., Savinova O.V., Effect of oral homoarginine supplementation on survival, cardiac structure and function in a mouse model of calcified coronary artery disease. J Am Heart Assoc. 2019 Jul 16;8(14):e012486.
  • Mangoni A.A., Rodionov R.N., McEvoy M., Zinellu A., Carru C., Sotgia S. New horizons in arginine metabolism, ageing and chronic disease states. Age Ageing. 2019 Nov 1;48(6):776-782
  • Karetnikova E.S., Jarzebska N., Markov A.G., Weiss N., Lentz S.R., Rodionov R.N. Homoarginine, a novel protective cardiovascular risk factor - hope or hype? Arterioscler Thromb Vasc Biol. 2019 May;39(5):869-875
  • Tanianskii D.A., Jarzebska N., Birkenfeld A.L., O'Sullivan J.F., Rodionov R.N. Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism. Nutrients. 2019 Feb 28;11(3).
  • Rodionov R.N., Heinrich A., Brilloff S., Martens-Lobenhoffer J., Bode-Böger S.M., Todorov V, Hugo C., Weiss N., Hohenstein B. ADMA reduction does not protect mice with streptozotocin-induced diabetes mellitus from development of diabetic nephropathy. Atheroscler Suppl. 2017 Nov;30:319-325
  • Burdin D.V., Kolobov A.A., Brocker C., Soshnev A.A., Samusik N., Demyanov A.V., Brilloff S., Jarzebska N., Martens-Lobenhoffer J., Mieth M., Maas R., Bornstein S.R., Bode-Böger S.M., Gonzalez F., Weiss N., Rodionov R.N. Hepatic Nuclear Factor 4α (HNF4α) is the major regulator of alanine-glyoxylate aminotransferase 2 (AGXT2) expression – a novel link between diabetes and impaired metabolism of endogenous methylarginines. Sci Rep. 2016 Oct 18;6:35503
  • Rodionov R.N., Oppici E., Martens-Lobenhoffer J., Jarzebska N., Brilloff S., Burdin D., Demyanov A.V., Kolouschek A., Leiper J., Maas R., Cellini B., Weiss N., Bode-Böger. A Novel Pathway for Metabolism of the Cardiovascular Risk Factor Homoarginine by alanine:glyoxylate aminotransferase 2. Sci Rep. 2016 Oct 18;6:35277
  • Rodionov R.N., Martens-Lobenhoffer J., Brilloff S., Burdin D.V., Jarzebska N., Demyanov A.V., Hohenstein B., Weiss N., Bode-Böger S.M. Acetylation of asymmetric and symmetric dimethylarginine – an undercharacterized pathway of metabolism of endogenous methylarginines. Nephrol Dial Transplant. 2016 Jan;31(1):57-63.
  • Rodionov R.N., Jarzebska N., Weiss N., Lentz S.R., AGXT2: a promiscuous aminotransferase. Trends Pharmacol Sci. 2014 Nov;35(11):575-82.
  • Rodionov R.N., Martens-Lobenhoffer J., Brilloff S., Hohenstein B., Jarzebska N., Jabs N., Kittel A., Maas R., Weiss N., Bode-Böger S.M., Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy. Nephrol Dial Transplant. 2014 Nov;29(11):2035-42.
  • Martens-Lobenhoffer J., Rodionov R.N., Bode-Böger S.M. Determination of asymmetric Nα-acetyl-dimethylarginine in humans: a phase II metabolite of asymmetric. Anal Biochem. 2014 May 1;452:25-30.
  • Lim S.K., Choi H., Park M.J., Kim D.I., Kim J.C., Kim G.Y., Jeong S.Y., Rodionov R.N., Han H.J., Yoon K.C., Park S.H. The ER stress-mediated decrease in DDAH1 expression is involved in formaldehyde-induced apoptosis in lung epithelial cells. Food Chem Toxicol. 2013 Oct 16
  • Deepa K., Rodionov R.N., Weiss N., Parani M. Transgenic Expression and Functional Characterization of Human Platelet Derived Growth Factor BB (hPDGF-BB) in Tobacco (Nicotiana tabacum L.). Appl Biochem Biotechnol. 2013 Aug 18
  • Kittel A., Maas R., König J., Mieth M., Weiss N., Jarzebska N., Hohenstein B., Martens-Lobenhoffer J., Bode-Böger S.M., Rodionov R.N., In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice. Biochem Biophys Res Commun. 2013 Jan 4;430(1):84-9.
  • Martens-Lobenhoffer J., Rodionov R.N., Bode-Böger S.M., Probing AGXT2 enzyme activity in mouse tissue by applying stable isotope-labeled asymmetric dimethyl arginine as substrate. J Mass Spectrom. 2012; 47: 1594-1600.
  • Martens-Lobenhoffer J., Rodionov R.N., Drust A, Bode-Böger S.M., Detection and quantification of a-keto-d-(NG,NG-dimethylguanidino)valeric acid (DMGV) in human plasma and urine: a metabolite of asymmetric dimethylarginine (ADMA) relevant for the nitric oxide homeostasis. Anal Biochem. 2011 Dec 15;419(2):234-40
  • Rodionov R.N., Murry D.J., Vaulman S.F., Stevens J.W., Lentz S.R. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. J Biol Chem. 2010 Feb 19;285(8):5385-91.
  • Rodionov R.N., Dayoub H., Lynch C.M., Wilson K.M., Stevens J.W., Murry D.J., Kimoto M., Arning E., Bottiglieri T., Cooke J.P., Baumbach G.L., Faraci F.M., Lentz S.R. Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res. 2010 Feb 19;106(3):551-8.
  • Rodionov R.N. and Lentz S.R. Many potential explanations for the homocysteine paradox. Arterioscler Thromb Vasc Biol. 2008 Oct; 28(10): e161.
  • Dayal S., Rodionov R.N., Arning E., Bottiglieri T., Kimoto M., Murry D.J., Cooke J.P., Faraci F.M., Lentz S.R. Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H816-25.
  • Rodionov R.N. and Lentz S.R. The Homocysteine Paradox. Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1031-3
  • Dayoub H., Rodionov R.N., Lynch C., Cooke J.P., Arning E., Bottiglieri T., Lentz S.R., Faraci F.M. Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke. 2008 Jan;39(1):180-4