Selected Publications
2024
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2023
Digomann D, Heiduk M, Reiche C, Glück J, Kahlert C, Mirtschink P, Klimova A, Bösch F, Tonn T, Gaedcke J, Ghadimi M, Weitz J, Seifert L, Seifert AM. Serum immune profiling identifies soluble CD40 as a biomarker for pancreatic cancer. NPJ Precis Oncol 2023
Heiduk M, Klimova A, Reiche C, Digomann D, Beer C, Aust DE, Distler M, Weitz J, Seifert AM*, Seifert L*. TIGIT expression delineates T cell populations with distinct functional and prognostic impact in pancreatic cancer. Clin Cancer Res 2023.
Digomann D, Strack J, Heiduk M, Plesca I, Rupp L, Reiche C, Nicolaus S, Beer C, Sommer U, Schmitz M, Distler M, Weitz J, Seifert AM, Seifert L. VISTA ligation reduces anti-tumor T cell activity in pancreatic cancer. Cancers 2023.
2022
Heiduk M, Glück J, Müller L, Plesca I, Digomann D, Reiche C, von Renesse J, Kahlert C, Sommer U, Aust DE, Schmitz M, Weitz J, Seifert L*, Seifert AM*. Neoadjuvant chemotherapy drives intratumoral T cells toward a pro-inflammatory profile in pancreatic cancer. JCI Insight 2022.
2021
Seifert L*, PlescaI*, MüllerL, SommerU, HeidukM, DigomannD, von RenesseJ, GlückJ, KlimovaA, WeitzJ, SchmitzM, Seifert AM. LAG-3-expressing tumor-infiltrating T cells are associated with reduced disease-free survival in pancreatic cancer. Cancers 2021.
2020
Seifert AM*, Eymer A*, Heiduk M, Wehner R, Tunger A, von Renesse J, Decker R, Aust DE, Welsch T, Reißfelder C, Weitz J, Schmitz M, Seifert L. PD-1 expression by lymph node and intratumoral regulatory T cells is associated with lymph node metastasis in pancreatic Cancer. Cancers 2020.
Seifert AM*, List J*, Heiduk M, DeckerR, von Renesse J, Meinecke A, Aust DE, Welsch T, Weitz J, Seifert L. Gamma-delta T cells stimulate IL-6-production by pancreatic stellate cells in pancreatic ductal adenocarcinoma. J Cancer Res Clin Oncol 2020.
Seifert AM*, Reiche C*, Heiduk M, Tannert A, Meinecke A, Baier S, von Renesse J, Kahlert C, Distler M, Welsch T, Reissfelder C, Aust DE, Miller G, Weitz J, Seifert L. Detection of pancreatic ductal adenocarcinoma with galectin-9 serum Levels. Oncogene. 2020.
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