Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold.
Schmäche T, Fohgrub J, Klimova A, Laaber K, Drukewitz S, Merboth F, Hennig A, Seidlitz T, Herbst F, Baenke F, Ada AM, Groß T, Wenzel C, Ball CR, Praetorius C, Schmidt T, Ringelband-Schilling B, Koschny R, Stenzinger A, Roeder I, Jaeger D, Zeissig S, Welsch T, Aust D, Glimm H, Folprecht G, Weitz J, Haag GM, Stange DE.
Mol Cancer. 2024 Jan 10;23(1):10.
Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.
Seidlitz T, Chen YT, Uhlemann H, Schölch S, Kochall S, Merker SR, Klimova A, Hennig A, Schweitzer C, Pape K, Baretton GB, Welsch T, Aust DE, Weitz J, Koo BK, Stange DE.
Gastroenterology. 2019 Dec;157(6):1599-1614.e2.
Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.
Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, Mort RL, Basak O, Clevers H, Stange DE, Philpott A, Kim JK, Simons BD, Koo BK.
Cell Stem Cell. 2019 Sep 5;25(3):342-356.e7.
Human gastric cancer modelling using organoids.
Seidlitz T, Merker SR, Rothe A, Zakrzewski F, von Neubeck C, Grützmann K, Sommer U, Schweitzer C, Schölch S, Uhlemann H, Gaebler AM, Werner K, Krause M, Baretton GB, Welsch T, Koo BK, Aust DE, Klink B, Weitz J, Stange DE.
Gut. 2019 Feb;68(2):207-217.
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.
Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, van Es JH, van de Wetering M, Mills JC, Clevers H.
Cell. 2013 Oct 10;155(2):357-68.
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.
Muñoz J*, Stange DE*, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H.
EMBO J. 2012 Jun 12;31(14):3079-91.
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling.
Wong VW*, Stange DE*, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB.
Nat Cell Biol. 2012 Mar 4;14(4):401-8.
Controlled gene expression in primary Lgr5 organoid cultures.
Koo BK*, Stange DE*, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H.
Nat Methods. 2011 Dec 4;9(1):81-3.
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
Stange DE, Engel F, Longerich T, Koo BK, Koch M, Delhomme N, Aigner M, Toedt G, Schirmacher P, Lichter P, Weitz J, Radlwimmer B.
Gut. 2010 Sep;59(9):1236-44.
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