Feto/neonatal Development

Project Content:

Better understanding of fetal organ development under intra- and extra-uterine conditions. Long term development is determined by organ development during the fetal period. However, fetal organ development can be disturbed intra-uterine, mainly due to maternal diseases, or during extra-uterine life of prematurely born infants. The group studies physiological organ development during intrauterine life and the impact of extra-uterine conditions on the fetal organ development. A tissue bank of various organs obtained from a unique extreme preterm baboon model was established (UTHSCSA, OHRI) in order to assess the impact of extreme preterm birth on physiology (UTHSCSA, KCL), histology (morphometry by stereology, MHH), transcriptome and proteome (CMCB) using unbiased methods.

Collaborations:

University of Texas Health Sciences Center at San Antonio (UTHSCSA), USA;

Medizinische Hochschule Hannover (MHH)

Group Leader

Marius Möbius

Publications

 Functional morphometry to estimate the alveolar surface area by using a premature baboon model. 

Dassios T, Rüdiger M, McCurnin D, Seidner SR, Williams EE, Greenough A, Möbius MA. J Appl Physiol. 2021 Dec 9. doi: 10.1152/japplphysiol.00644.2021. Online ahead of print.

 Systematic analysis of candidate reference genes for gene expression analysis in hyperoxia-based mouse models of bronchopulmonary dysplasia. 

Linge M, Möbius MA, Rösen-Wolff A, Winkler S. Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L718-L725. doi: 10.1152/ajplung.00143.2021. Epub 2021 Aug 11.

Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.   

O'Reilly M, Möbius MA, Vadivel A, Ionescu L, Fung M, Eaton F, Greer JJ, Thébaud B.  Stem Cells Dev. 2020 Mar 15;29(6):364-371. doi: 10.1089/scd.2019.0116. Epub 2020 Feb 10.Stem Cells Dev. 2020.    

Oxygen Disrupts Human Fetal Lung Mesenchymal Cells. 

Implications for Bronchopulmonary Dysplasia. Möbius MA, Freund D, Vadivel A, Koss S, McConaghy S, Ohls RK, Rüdiger M, Thébaud B. Am J Respir Cell Mol Biol. 2019 May;60(5):592-600. doi: 10.1165/rcmb.2018-0358OC    

 Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs. 

Collins JJ, Möbius MA, Thébaud B.  J Vis Exp. 2016 Jun 17;(112):53782. doi: 10.3791/53782.J Vis Exp. 2016.