Neurology-Psychiatry
Neurological diseases in childhood and adulthood are often accompanied by (progressive) physical and mental disability. These diseases occur at all stages of life and are characterised by a significant tendency towards progression, chronification and/or recurrent episodes of disease with loss of neural function and mental health.
Neurodegeneration may be the cause or consequence of the underlying pathophysiology. Many neurodegenerative diseases have genetic causes. In addition to physical symptoms, such patients often suffer from neuropsychological and psychiatric comorbidities, which often cause the greater demands on the care of these patients. Genetic causes are not only relevant for diseases discovered in childhood, but foreseeably also for adults with neurodegenerative diseases. The identification of genetic causes can help to implement appropriate support measures and preventive examinations as well as interdisciplinary medical care and to provide assistance in family planning. In addition, causal therapies are available for more and more genetic diseases, which can be offered, for example, within the framework of studies.
Other focal points of the neuroscience clinics and institutes of the USE are myopathies and mitochondrial diseases. Both disease groups can be caused by rare inflammatory, autoimmune or genetic causes. The clinical symptoms of these patients often affect several organ systems (in addition to neurology, cardiology, pulmonology, endocrinology, orthopaedics), so that interdisciplinary care of the patients is of great importance. In the field of mitochondrial diseases, the ZSE (Mitochondrial Laboratory of the Neuro-Cluster) offers a wide range of molecular genetic mitochondrial diagnostics with DAkkS accreditation, which is also available to external senders nationwide.
The Clinic and Polyclinic for Neurology, KClinic and Polyclinic for Paediatrics and Adolescent Medicine, Department of Neuropaediatrics, the Institute for Clinical Genetics nstitut für Klinische Genetik and the Clinic and Polyclinic for Psychiatry and Psychotherapy are integrated into the cluster.
Diseases and associated institutions
Disease
Rare neurodegenerative diseases and their differential diagnoses:
- Parkinson's syndromes (idiopathic Parkinson's syndrome, atypical Parkinson's syndromes).
- Huntington's disease
- Motor neurone disease (ALS)
- Spinal muscular atrophy
- Dementia syndromes (Alzheimer's type dementia (sporadic and familial form), frontotemporal dementias, Lewy body dementia)
- Wilson's disease
Developmental disorders:
Syndromal and non-syndromal developmental disorders.
Genetic brain malformations, especially disorders of cortex development . (Lissencephaly polymicrogyria, polymicrogyria-like malformations, heterotopias)
Rare and as yet unclassified dysmorphic syndromes
Baraitser-Winter syndrome
Microcephalies in childhood
Neurofibromatosis in childhood
Neurometabolic diseases:
Rare and refractory epilepsies in childhood and adulthood:
- Reflex epilepsies
- Progressive myoclonus epilepsy
- Epileptic encephalopathies
- Autoimmune encephalitides
- Use of ketogenic or modified Atkins diet
Muscle centre/neuromuscular diseases:
- Muscular dystrophies
- Myofibrillar myopathies
- Myositides, Mito-PM
- Myasthenic syndromes
- Metabolic myopathies
- Pompe's disease
- (Non) dystrophic myotonia
- Hereditary neuropathies
Life-limiting neurological diseases in childhood:
- Development of treatment concepts in the context of specialised paediatric palliative care, SAPPV
Special consultation hours
- Special consultation for movement disorders, Parkinson's syndromes, Huntington's disease (NEU)
Prof. Dr. med. Björn Falkenburger
Further Information >>
- Special consultation for motor neuron diseases (NEU)
Dr. med. René Günther
Further Information >> - Special consultation for Wilson's disease (NEU)
Dr. med. Ulrike Reuner
Further Information >> - Special consultation for epilepsy (NEU)
Dr. med. Georg Leonhardt
Further Information > - Special consultation for muscle diseases ( (NEU)
Dr. med. Annika Saak
Further Information >> - Special consultation for mitochondrial diseases (NEU)
Dr. med. Jochen Schäfer
Further Information >> - University Dementia Centre, special consultation for mild cognitive impairment in advancing age and dementia; dementia of the Alzheimer type, vascular dementia, Lewy body dementia, frontotemporal dementias (PSY/NEU)
Prof. Dr. med. Dr. rer. medic. Markus Donix, PD Dr. med. Moritz Brandt
Further Information >> - Special consultation for neurological sleep disorders: Narcolepsy and other hypersomnias, parasomnias (NEU)
PD Dr. med. Moritz Brandt - Special consultation for neuromuscular diseases in childhood and adolescence (KIN)
Prof. Dr. med. Maja von der Hagen
Further Information >> - Special consultation for therapeutic epilepsies in childhood and ketogenic or modified Atkins diet (KIN)
Dr. med. Dolores Friebel, Dr. med. Silvia Kinder
Further Information >> - Special consultation for (extrapyramidal) movement disorders in children and adolesce (KIN)
Dr. med. Martin Smitka
Further Information >> - Special consultation for combined syndromal developmental disorders in childhood(KIN)
Dr. med. Jens Schallner
Further Information >> - Special consultation for neurofibromatosis in childhood (KIN)
Dr. med. Martin Smitka
Further Information >> - Special consultation hour for mental developmental delay/developmental disorder (KGE)
Dr. med. Nataliya Donato
Further Information >> - Special consultation for brain malformations and syndromal disorders (KGE)
Dr. med. Nataliya Di Donato
Further Information >>
Integration into existing research networks
German Parkinson's Disease Network (KNP)
European Huntington´s Disease Network (EHDN)
German Motor Neurone Disease Network (MND NET)
European Huntington´s Disease Network
German Centre for Neurodegenerative Diseases (DZNE)
European Network of Excellence “Translational Research in Europe for the Assessment and Treatment of Neuromuscular Disease” TREAT- NMD
German Network for Research on Autoimmune Encephalitis
German Network for Mitochondrial Diseases (mitoNet)
Ataxia Global Initiative (AGI)
European Reference Network for rare neurological diseases (ERN-RND)